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1

Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action

Felter, Susan P., Foreman, Jennifer E., Boobis, Alan, Corton, J. Christopher, Doi, Adriana M., Flowers, Lynn, Goodman, Jay, Haber, Lynne T., Jacobs, Abigail, Klaunig, James E., Lynch, Angela M., Moggs

Journal:

Regulatory Toxicology and Pharmacology

Year:

2018

Language:

english

File:

PDF, 242 KB

english, 2018

2

Risk Benefit Assessment of foods: Key findings from an international workshop

Pires, Sara M., Boué, Géraldine, Boobis, Alan, Eneroth, Hanna, Hoekstra, Jeljer, Membré, Jeanne-Marie, Persson, Inez Maria, Poulsen, Morten, Ruzante, Juliana, van Klaveren, Jacob, Thomsen, Sofie T., N

Journal:

Food Research International

Year:

2018

Language:

english

File:

PDF, 1.95 MB

english, 2018

3

Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers

Ritva Piipari, Kirsti Savela, Tuula Nurminen, Janne Hukkanen, Hannu Raunio, Jukka Hakkola, Timo Mäntylä, Philippe Beaune, Robert J. Edwards, Alan R. Boobis, Sisko Anttila

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 107 KB

english, 2000

4

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism

Christoph Sachse, Upinder Bhambra, Gillian Smith, Tracy J. Lightfoot, Jennifer H. Barrett, Jenna Scollay, R. Colin Garner, Alan R. Boobis, C. Roland Wolf, Nigel J. Gooderham, The Colorectal Cancer Stu

Journal:

British Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 152 KB

english, 2003

5

Mechanisms of cell death

Duncan J. Fawthrop, Alan R. Boobis, Donald S. Davies

Journal:

Archives of Toxicology

Year:

1991

Language:

english

File:

PDF, 983 KB

english, 1991

6

Evidence for a direct role of intracellular calcium in paracetamol toxicity

Alan R. Boobis, Caroline E. Seddon, Pari Nasseri-Sina, Donald S. Davies

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 667 KB

english, 1990

7

Mechanisms of cell death

Alan R. Boobis, Duncan J. Fawthrop, Donald S. Davies

Journal:

Trends in Pharmacological Sciences

Year:

1989

Language:

english

File:

PDF, 1.23 MB

english, 1989

8

Establishing the level of safety concern for chemicals in food without the need for toxicity testing

Schilter, Benoît, Benigni, Romualdo, Boobis, Alan, Chiodini, Alessandro, Cockburn, Andrew, Cronin, Mark T.D., Lo Piparo, Elena, Modi, Sandeep, Thiel, Anette, Worth, Andrew

Journal:

Regulatory Toxicology and Pharmacology

Year:

2014

Language:

english

File:

PDF, 2.24 MB

english, 2014

9

Testicular Dysgenesis Syndrome and the Estrogen Hypothesis: A Quantitative Meta-Analysis

Olwenn V. Martin, Tassos Shialis, John N. Lester, Mark D. Scrimshaw, Alan R. Boobis and Nikolaos Voulvoulis

Journal:

Environmental Health Perspectives

Year:

2008

Language:

english

File:

PDF, 2.87 MB

english, 2008

10

Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment

Boobis, Alan, Budinsky, Robert, Collie, Shanna, Crofton, Kevin, Embry, Michelle, Felter, Susan, Hertzberg, Richard, Kopp, David, Mihlan, Gary, Mumtaz, Moiz, Price, Paul, Solomon, Keith, Teuschler, Lin

Journal:

Critical Reviews in Toxicology

Year:

2011

Language:

english

File:

PDF, 877 KB

english, 2011

11

Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver

Barter, Zoe, Bayliss, Martin, Beaune, Philip, Boobis, Alan, Carlile, David, Edwards, Robert, Brian Houston, J., Lake, Brian, Lipscomb, John, Pelkonen, Olavi, Tucke, Geoffrey, Rostami-Hodjegan, Amin

Journal:

Current Drug Metabolism

Year:

2007

Language:

english

File:

PDF, 850 KB

english, 2007

12

Instruments for Assessing Risk of Bias and Other Methodological Criteria of Animal Studies: Omission of Well-Established Methods

Beck, Nancy B., Becker, Richard A., Boobis, Alan, Fergusson, Dean, Fowle, John R., Goodman, Julie, Hoffmann, Sebastian, Lalu, Manoj, Leist, Marcel, Stephens, Martin L.

Journal:

Environmental Health Perspectives

Year:

2014

Language:

english

File:

PDF, 203 KB

english, 2014

13

The role of hazard- and risk-based approaches in ensuring food safety

Barlow, Susan M., Boobis, Alan R., Bridges, Jim, Cockburn, Andrew, Dekant, Wolfgang, Hepburn, Paul, Houben, Geert F., König, Jürgen, Nauta, Maarten J., Schuermans, Jeroen, Bánáti, Diána

Journal:

Trends in Food Science & Technology

Year:

2015

Language:

english

File:

PDF, 384 KB

english, 2015

14

Considering new methodologies in strategies for safety assessment of foods and food ingredients

Blaauboer, Bas J., Boobis, Alan R., Bradford, Bobbie, Cockburn, Andrew, Constable, Anne, Daneshian, Mardas, Edwards, Gareth, Garthoff, Jossie A., Jeffery, Brett, Krul, Cyrille, Schuermans, Jeroen

Journal:

Food and Chemical Toxicology

Year:

2016

Language:

english

File:

PDF, 839 KB

english, 2016

15

Allowing pseudoscience into EU risk assessment processes is eroding public trust in science experts and in science as a whole: the bigger picture

Dietrich, Daniel R., Dekant, Wolfgang, Greim, Helmut, Heslop-Harrison, Pat, Berry, Sir Colin, Boobis, Alan, Hengstler, Jan, Sharpe, Richard

Journal:

Chemico-Biological Interactions

Year:

2016

Language:

english

File:

PDF, 982 KB

english, 2016

16

Thresholds of Toxicological Concern for cosmetics-related substances: New database, thresholds, and enrichment of chemical space

Yang, Chihae, Barlow, Susan M., Muldoon Jacobs, Kristi L., Vitcheva, Vessela, Boobis, Alan R., Felter, Susan P., Arvidson, Kirk B., Keller, Detlef, Cronin, Mark T.D., Enoch, Steven, Worth, Andrew, Hol

Journal:

Food and Chemical Toxicology

Year:

2017

Language:

english

File:

PDF, 5.60 MB

english, 2017

17

Perâ and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research

Fenton, Suzanne E., Ducatman, Alan, Boobis, Alan, DeWitt, Jamie C., Lau, Christopher, Ng, Carla, Smith, James S., Roberts, Stephen M.

Journal:

Environmental Toxicology and Chemistry

Year:

2020

File:

PDF, 863 KB

2020

18

Expression and inducibility of P450 enzymes during liver ontogeny

Rich, Kim J., Boobis, Alan R.

Journal:

Microscopy Research and Technique

Year:

1997

Language:

english

File:

PDF, 679 KB

english, 1997

19

Expression and distribution of CYP2C enzymes in rat basal ganglia

Andrew G. Riedl, Paul M. Watts, Daniel C. Douek, Robert J. Edwards, Alan R. Boobis, Sarah Rose, Peter Jenner

Journal:

Year:

2000

Language:

english

File:

PDF, 794 KB

english, 2000

20

Determination of the N-acetyl metabolites of 4,4′-methylene dianiline and 4,4′-methylene-bis(2-chloroaniline) in urine

John Cocker, Alan R. Boobis, Donald S. Davies

Journal:

Biological Mass Spectrometry = Journal of Mass Spectrometry (Wiley)

Year:

1988

Language:

english

File:

PDF, 569 KB

english, 1988

21

The metabolic activation of 4,4′-methylene-bis-(2-chlorobenzeneamine) to a bacterial mutagen by hepatic postmitochondrial supernatant from human and other species

John Cocker, Alan R. Boobis, Jane F. Gibson, Donald S. Davies

Journal:

Environmental and Molecular Mutagenesis

Year:

1985

Language:

english

File:

PDF, 530 KB

english, 1985

22

A radiometric high-pressure liquid chromatography assay for the simultaneous determination of the three main oxidative metabolites of antipyrine in studies in vitro

G. Clare Kahn, Alan R. Boobis, Ian A. Blair, Martin J. Brodie, Donald S. Davies

Journal:

Analytical Biochemistry

Year:

1981

Language:

english

File:

PDF, 663 KB

english, 1981

23

Rapid analysis for metabolites of 11C-labelled drugs: fate of [11C]-S-4-(tert.-butylamino-2-hydroxypropoxy)-benzimidazol-2-one in the dog

Hazel A. Jones, Christopher G. Rhodes, Marilyn P. Law, Jennifer M. Becket, John C. Clark, Alan R. Boobis, Graham W. Taylor

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1991

Language:

english

File:

PDF, 453 KB

english, 1991

24

Exposure to and activation of dietary heterocyclic amines in humans

Anthony M. Lynch, Stephen Murray, Nigel J. Gooderham, Alan R. Boobis

Journal:

Critical Reviews in Oncology/Hematology

Year:

1995

Language:

english

File:

PDF, 1.61 MB

english, 1995

25

The future of mixture toxicology

Journal:

Year:

2007

Language:

english

File:

PDF, 47 KB

english, 2007

26

Proteomic analysis of the differential effects of estrogens on human breast cancer cells

Zheying Zhu, Alan R. Boobis, Robert J. Edwards

Journal:

Year:

2007

Language:

english

File:

PDF, 123 KB

english, 2007

27

Paracetamol oxidation: synthesis and reactivity of N-acetyl-p-benzoquinoneimine

Ian A. Blair, Alan R. Boobis, Donald S. Davies, Terry M. Cresp

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 210 KB

english, 1980

28

COST B15: modelling in drug development

Leon Aarons, Luc Balant, Alan Boobis

Journal:

British Journal of Clinical Pharmacology

Year:

2001

Language:

english

File:

PDF, 31 KB

english, 2001

29

Dissecting the function of cytochrome P450

ALAN R. BOOBIS, ROBERT J. EDWARDS, DELYTH A. ADAMS, DONALD S. DAVIES

Journal:

British Journal of Clinical Pharmacology

Year:

1996

Language:

english

File:

PDF, 306 KB

english, 1996

30

C-Terminal antibodies (CTAbs): A simple and broadly applicable approach for the rapid generation of protein-specific antibodies with predefined specificity

Robert J. Edwards, Amanda Wrigley, Zhonghu Bai, Michaela Bateman, Hugh Russell, Stephen Murray, Huafeng Lu, Graham W. Taylor, Alan R. Boobis, Shiranee Sriskandan

Journal:

Year:

2007

Language:

english

File:

PDF, 375 KB

english, 2007

31

Identification of estrogen-responsive proteins in MCF-7 human breast cancer cells using label-free quantitative proteomics

Zheying Zhu, Alan R. Boobis, Robert J. Edwards

Journal:

Year:

2008

Language:

english

File:

PDF, 540 KB

english, 2008

32

Is the activation of aflatoxin B1catalysed by the same form of cytochrome P-450 as that 4-hydroxylating debrisoquine in rat and/or man?

Simon Plummer, Alan R. Boobis, Donald S. Davies

Journal:

Archives of Toxicology

Year:

1986

Language:

english

File:

PDF, 559 KB

english, 1986

33

Paracetamol toxicity in hamster isolated hepatocytes: The increase in cytosolic calcium accompanies, rather than precedes, loss of viability

Simon J. Hardwick, James W. Wilson, Duncan J. Fawthrop, Alan R. Boobis, Donald S. Davies

Journal:

Archives of Toxicology

Year:

1992

Language:

english

File:

PDF, 495 KB

english, 1992

34

Meta-analysis of Studies of Alcohol and Breast Cancer with Consideration of the Methodological Issues

Jane Key, Susan Hodgson, Rumana Z. Omar, Tina K. Jensen, Simon G. Thompson, Alan R. Boobis, Donald S. Davies, Paul Elliott

Journal:

Cancer Causes & Control

Year:

2006

Language:

english

File:

PDF, 197 KB

english, 2006

35

Determination of a Human Hepatic Microsomal Scaling Factor for Predictingin VivoDrug Clearance

Nancy Hakooz, Kiyomi Ito, Helen Rawden, Helen Gill, Lynn Lemmers, Alan R. Boobis, Robert J. Edwards, David J. Carlile, Brian G. Lake, J. Brian Houston

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 369 KB

english, 2006

36

Systematic review of epidemiological evidence for use in the framework approach for analysing the human relevance of an animal mode of action

Ehi Idahosa, Lesley Rushton, Alan R. Boobis

Journal:

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

37

Mass spectrometric detection and measurement of N2-(2′-deoxyguanosin-8-yl)PhIP adducts in DNA

Sarah J Crosbie, Stephen Murray, Alan R Boobis, Nigel J Gooderham

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

2000

Language:

english

File:

PDF, 183 KB

english, 2000

38

Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension

Gideon A. Paul, J Simon R. Gibbs, Alan R. Boobis, Allifia Abbas, Martin R. Wilkins

Journal:

British Journal of Clinical Pharmacology

Year:

2005

Language:

english

File:

PDF, 131 KB

english, 2005

39

Expression of Cytochromes P450 3A and P-Glycoprotein in Human Large Intestinse in Paired Tumour and Normal Samples

Roberto Canaparo, Anna Nordmark, Niklas Finnström, Stefan Lundgren, Janeric Seidegård, Bengt Jeppsson, Robert J. Edwards, Alan R. Boobis, Anders Rane

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2007

Language:

english

File:

PDF, 237 KB

english, 2007

40

Mode of Action Considerations in the Quantitative Assessment of Tumour Responses in the Liver

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2010

Language:

english

File:

PDF, 188 KB

english, 2010

41

Proceedings of the Final Congress of COST Action B25: Physiologically Based Pharmaco-Toxicokinetics and Dynamics, held in Athens, 26–27 May 2009

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

42

Effect of isoniazid on vitamin D metabolism and hepatic monooxygenase activity

Brodie, Martin J, Boobis, Alan R, Hillyard, Carmel J, Abeyasekera, Gamini, Maclntyre, Ian, Park, B Kevin

Journal:

Clinical Pharmacology & Therapeutics

Year:

1981

Language:

english

File:

PDF, 286 KB

english, 1981

43

Managing the challenge of chemically reactive metabolites in drug development

Park, B. Kevin, Boobis, Alan, Clarke, Stephen, Goldring, Chris E. P., Jones, David, Kenna, J. Gerry, Lambert, Craig, Laverty, Hugh G., Naisbitt, Dean J., Nelson, Sidney

Journal:

Nature Reviews Drug Discovery

Year:

2011

Language:

english

File:

PDF, 752 KB

english, 2011

44

Diazinon Is Activated by CYP2C19 in Human Liver

Wendela A. Kappers, Robert J. Edwards, Stephen Murray, Alan R. Boobis

Journal:

Toxicology and Applied Pharmacology

Year:

2001

Language:

english

File:

PDF, 93 KB

english, 2001

45

Kinetics of Lung Macrophages Monitored in Vivo Following Particulate Challenge in Rabbits

Hazel A. Jones, Sven O. Valind, Ian C. Clark, Geraldine E. Bolden, Thomas Krausz, John B. Schofield, Alan R. Boobis, Christopher Haslett

Journal:

Toxicology and Applied Pharmacology

Year:

2002

Language:

english

File:

PDF, 466 KB

english, 2002

46

In vitro prediction of gastrointestinal absorption and bioavailability: an experts' meeting report

Pelkonen, Olavi, Boobis, Alan, Gundert-Remy, Ursula

Journal:

European Journal of Clinical Pharmacology

Year:

2001

Language:

english

File:

PDF, 119 KB

english, 2001

47

Reversal of acetaminophen toxicity in isolated hamster hepatocytes by dithiothreitol

Lisa B.G. Tee, Alan R. Boobis, Anthony C. Huggett, Donald S. Davies

Journal:

Toxicology and Applied Pharmacology

Year:

1986

Language:

english

File:

PDF, 11.30 MB

english, 1986

48

An inhibitory monoclonal anti-protein antibody and an anti-peptide antibody share an epitope on rat cytochrome P-450 enzymes CYP1A1 and CYP1A2

Robert J. Edwards, Bernard P. Murray, Stephen Murray, Alison M. Singleton, Donald S. Davies, Alan R. Boobis

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1993

Language:

english

File:

PDF, 977 KB

english, 1993

49

Positron emission tomography in the quantification of cellular and biochemical responses to intrapulmonary particulates

Hazel A. Jones, Kurt Hamacher, John C. Clark, John B. Schofield, Thomas Krausz, Christopher Haslett, Alan R. Boobis

Journal:

Toxicology and Applied Pharmacology

Year:

2005

Language:

english

File:

PDF, 241 KB

english, 2005

50

Development of a Comprehensive Panel of Antibodies against the Major Xenobiotic Metabolising Forms of Cytochrome P450 in Humans

Robert J Edwards, Delyth A Adams, Patricia S Watts, Donald S Davies, Alan R Boobis

Journal:

Biochemical Pharmacology

Year:

1998

Language:

english

File:

PDF, 493 KB

english, 1998